Standardization and evaluation of herbal medicinal preparations
standardization & evaluation of herbal medicinal preparations 1BN PG Girls College of Pharmacy, Udaipur-
Raj.INDIA 313 002
: – In recent years there has been huge demand for plant-derived products in the developed countries. These products are increasingly used as medicines, food supplements & cosmetics sought. (1) There are about 6,000 vegetable producers in India. More than 4,000 units produced Ayurvedic medicine. Due into lack of infrastructure, skilled manpower, reliable methods & strict legal rules, most of these manufacturers produce their products at a very conservative basis. (2)
The standardization of crude drug materials include the following steps: –
authentication: – Each step must be authenticated.
a) phase of the collection.
Leaf constant: – palisade ratio, vein island number, vein termination stomatal number & stomatal index. Trichomes. Stomata. Quantitative Microscopy. Taxonomic identity. Foreign body. Sensory evaluation. Ash values & extractive values. Moisture content determination. Chrometographic & spectroscopic analysis. Heavy metal determination. Pesticide residues. Microbial contamination. Radioactive contamination.
herbal formula in general can be schematically standardize into the drug with raw materials from different places & a comparative chemical action must be formulated in different batches collected formulation observed. The preparations with better clinical efficacy are into be selected. be reviewed after all the routine physical, chemical & pharmacological parameters for all lots into select the final finished product & validate the entire manufacturing process. (6)
color, odor include, appearance, clarity, viscosity, moisture, pH, disintegration time, friability, hardness, flow properties, flocculation, sedimentation, settling velocity & ash values.
limit tests, chemical tests, chemical tests can etc.of herbs with TLC, HPLC, HPTLC, GC, UV, GC-MS, fluorimetry, etc.
total viable content, total mold count of enterobacteria & their total count. Limiter as a quantitative or semi-quantitative tool into identify & control the amount of impurities such as reagents during abstraction can be used by different herbs are used come directly from impurities in the manufacture of ships & the solvent etc.
The topic of the herbal drug standardization massively wide & deep. The WHO guidelines can be summarized as follows: –
: – Sensory evaluation, foreign body, microscopy measurement.
fluorescence quenching use of fingerprints & marker compounds for identification & standardization of botanical drugs are used Densitometric thin layer chromatographic determination of escin in a herbal medicine with Asculum & Vitis dry Determination of stigmasterol, beta – sitosterol & stigma stanine in oral dosage forms using HPLC with evaporative light scattering detection: – Elemental analysis of herbal preparations for traditional medicines by neutron activation analysis with the standardization method kO: – liquid chromatography & liquid chromatography-UV determination Atmospheric pressure chemical ionization mass spectrometric characterization of sitosterol & stigmasterol in soybean oil: – Simultaneous determination of cinnamaldehyde, eugenol & paeonol in traditional Chinese medicine preparations by capillary GC FID: – HPTLC fingerprinting of the marketed formulation with Shankhpushpi: biological parameters (bioassay ):- adaptogenic activity profile evaluation of the herbal preparation: – help Evaluation of the antioxidant activity of herbal products: – assessment of microbial contamination reduction on plants through technological process of decoction & spray dry: – The technological process of raw material has many phases, usually, unwanted microbial growth but the complete elimination is used by the training & working condition. The goal of this study was into evaluate the microbial contamination, such as mineral solution (SE) & check spray dried extract (PSA) with the purpose of evaluation of reduction of contamination after boiling & spray dry. The microbiological analysis of the products was carried out of a total of germs & bacteria MPN. (19)
Evaluation of nitric oxide scavenging activity of selected medicinal plants in inflammatory diseases : – Four traditional medicinal plants, namely Ventilago madraspatana Gaertn., Rubia cordifolia Linn., Lanatana Camara Linn. And Morinda citrifolia Linn Were. for a study on the inhibition of nitric oxide (NO), a central role in the phenomenon of inflammation indicates the presence of effective anti-inflammatory components selected in it. Plant samples were spiked with different solvents into evaluate their inhibitory effect on NO produced in vitro from sodium nitroprusside & extracted in LPS-activated murine peritoneal macrophages ex vivo (20).The lipid peroxidation inhibitory activity: – The reaction mixture contained mice liver homogenate (0.2 ml, 10% w / v) in 0.15 KCl, KCl (0.1 ml, 150 pm ), Tris buffer (0.4 ml, pH 7.5) & various concentrations of test extracts. In vitro lipid peroxidation initiated by the addition of FeSO4.7H2O (0.1 ml, 10 pm). The reaction mixture was incubated at 37o 1 h after the incubation period was the reaction by adding thiobarbituric acid (TBA-2 ml, 0.8% finished) & min by heating the contents for 15th for the development of colored complex. The tubes were then at 4000 rpm for centrifuged for 10 minutes. cool and. The% inhibition of lipid peroxidation was determined by comparing the results of the test substance with those of the control never treated with extracts by monitoring the intensity determined at 532 nm. gallic acid was used as positive control. (21) evaluation of the marketed antidiabetic polyherbal formulatios with biomarkers: – in vivo & Shoe in vitro evaluation of hair growth potential of flower: Clinical evaluation of the safety & efficacy of herbal medicine coded “Dysmo-off” vs traditional medicine “Diclofenac sodium “Check for the treatment of primary dysmenorrhea: – Thermographic Rating: Biochemical Rating: Evaluation Kutaj-Ghanavati for alkaloidal principles: – Sensory Evaluation:
The theme is the herbal drug standardization massively wide & deep. It is so much into know & so much seemingly contradictory theories about herbal medicine & its relationship with human physiology & mental functions.
Bhanu Sagar PS, Zafar R., R. Panwar, “drug standardization”, the Indian chemist, vol. 4 (35) , May 2005, 2005, pp.19-22. Patel PM, Patel NM, Goyal RK, “Evaluation of the marketed antidiabetic polyherbal formulations used charantin biomarkers” The Pharma Review, Vol 4 (22), June 2006, pp.113. PM Patel, Patel NM, Goyal RK, “Quality control for herbal products”, the Indian chemist, Vol.5 (45), March 2006, pp.26-30. Bhutani KK, “Herbal medicine a mystery & challenge of science & directions for new initiatives “, Indian Journal of Natural Products, Vol.19 (1), March 2003, pp.3-8. Kokate CK, Purohit AP ., Gokhale SB, “Analytical Pharmacognosy, Pharmacognosy, 30th edition, February 2005, p.1, 99 Shrikumar S., U. Maheshwari, A. Sughanti, Ravi TK,” WHO guidelines for herbal medicine standardization, “2006th Ansari SH , “Standardization of crude drugs” Essentials of Pharmacognosy, I. edition, 2005-06, S.14, 581st SB Gokhale, Surana SJ, “fluorescence quenching as a tool for identification & quality control of raw drugs, Planta Indica, Vol 2 (3), July 2006, pp.47. Shaw PC, Pui-hat Butt P., “Authentication of Panax species & their distorted by random primed Polymerase Chain Reaction”, Planta Medica, vol. 61, 1995, pp.466- 469th Lazarowych NJ, Pekos P., “Use of fingerprinting & marker compounds for identification & standardization of botanical drugs: strategies for applying pharmaceutical HPLC analysis into herbal products,” Drug Information Journal, Vol.32, 1998, pp .497-512. Apers S, Naessens T, Pieters L., Vlietinck A. “Densitometric thin-layer chromatographic determination of escin in a herbal medicinal product of Aesculus & Vitis dry”, Jr. of the chromatographic analysis, vol.1112 (1 – 2), April 2006, pp.165-170. VD Nair, I. Kanfer, Hoogmartens J., “Determination of stigmasterol, beta-sitosterol & stigma stanine in oral dosage forms using HPLC with evaporative light scattering detection”, Journal of pharmaceutical & biomedical Analysis, vol. 41 (3), June 2006, pp. 731-737. Sarmani SB, Abugassa I., Hamzah A., MD Yahya, “Elemental analysis of herbal preparations for traditional medicines by neutron activation analysis with the standardization method kO” , Biological Trace Element Research, 1999, pp. 365-376. Careri M., Elviri L., A. Mangia, Liquid chromatography-UV determination & liquid chromatography-atmospheric pressure chemical ionization mass spectrometric characterization of sitosterol & stigmasterol in soybean oil “, Jr. of the chromatographic analysis, vol. 935 (1-2), Nov.2001, pp.249-257. Yu BS, SG Lai, Tan QL, “Simultaneous determination of cinnamaldehyde, eugenol & paeonol by in traditional Chinese medicine preparations capillary GC-FID, chemical & pharmaceutical Bulletin, vol. 54 (1), Jan 2006, pp. 114-116. MK Santosh, Shaila D., Sanjeeva Rao, I., “Standardization & study of dadimastaka pushyannga Churnas” Asian Jr. of Chemistry, vol. 16 (34), 2004, pp. 1735-1741. Azamathulla Shaik, Hule Amolkumar, “Evaluation of adaptogenic activity profile of herbal preparation”, Indian Jr. of Experimental Biology, vol. 44, July 2006, pp.574-579th Zaporozhets OA, Lipkovska NA, “A new test method for evaluating the total antioxidant activity of herbal products,” Jr. of Agricultural & Food Chemistry, vol. 52 (1), 2004, pp.21-25. De Souza TP, Zulian Lionzo MI, “Evaluation of microbial contamination reduction on plants through technological process of decoction & spray dry”, Brazilian Jr. of Pharmacognosy, vol. 16 (1), 2006, pp.94-98. Basu S ., Hazra B., “Evaluation of nitric oxide scavenging activity of selected medicinal plants used in inflammatory diseases”, Phytotherapy Research, vol. 20 (10), 2006, pp. 896-900. Shinde AD, Bhise SB, “Evaluation of wound healing activity the herbal drug combination of Tridax Procumbens, Azadirachta indica, Curcuma longa & Apis mellifera, “Indian Drugs, vol. 41 (6), June 2004, pp.376-378th Adhiraj N., T. Ravikumar, Shanmugasundaram N.,” In vivo & in vitro evaluation of hair growth potential of Shoe Flower, Jr. of ethanopharmacology, vol. 88 (2-3), 2003, pp. 235-239. Nazar H., Usmanghani K., “Clinical Review toi evaluate the safety & efficacy of herbal medicine coded “Dysmo-off” vs traditional medicine “Diclofenac sodium for the treatment of primary dysmenorrhea,” Herb Jr. Pharmacotherapy, vol. 6 (1), 2006, pp.21-39. Inokawa M., Iguchi K., Kohda H., “Thermographic evaluation of the efficacy of Kampo Medicine, Hiroshima Jr. Med Sci., Vol 55 (1), March 2006, p.1-8. Palani V., Senthilkumaran RK, “Biochemical evaluation of antitumor effect of Muthu Marunthu on experimental fibrosarcoma in rats”, Jr. of Ethanopharmacology, vol. 65 (3), 1999, pp.257-265. Bhavasar GC, Pundarikakshudu K., “Evaluation of Kutaj -Ghanvati for alkaloidal principles, “Indian Jr. Natural Products, vol. 20 (1), 2003, pp.33. HR Sharma, P. Verma, organoleptic & chemical analysis of the osmotically processed apricot halves & wholes, natural product Radiance , Vol.5 (3), Sept-Oct 2006, pp.350-356. Boullata IJ, NACE MA, “Safety problem with herbal medicine,” Pharmacotherapy, vol. 20 (3), 2000, pp.257-269.
pharmacology Video Rating: 5.3
Incoming search terms:
- shankhpushpi hplc, steps of standardization drugs, Chromatographic Fingerprint Analysis of Herbal Medicines download, Standardization of crude - Ansari S H, standardization of herbal drugs, standardization of herbal medicine pdf, standardization of the herbal product, the pharma review vol 4 (22) june 2006 pp 113, theories on herbal medicinal effects of curcuma/ pdf, trace element in medicinal plants
Related posts:
- Herbal Beverages its uses and benefits
- Compounding sterile preparations Video Training Program (Book + DVD)
- Complex Complete Herbal Medicines
- Herbal Products: Toxicology and Clinical Pharmacology
- A Modern Herbal
- First evaluation of suspected DEMENTIA Asking the right questions
- The Herbal Drugstore
- Asian Ginseng – Medicinal Uses, Interactions, Side Effects, Dosage
Tags: Evaluation, Herbal, Medicinal, preparations, Standardization
